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Contraindicated (1)pentobarbital will lower the level or impact of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females mustn't choose estradiol valerate/dienogest as their contraceptive while using potent CYP3A4 inducers due to prospective minimize in contraceptive efficacy.pentobarbital w